Published On: Sat, Jul 13th, 2019

Children who were prenatally exposed to opioids went on to have lower IQ scores than those who weren’t exposed to the medications, according to a new study (n= 1,455). They also have more physical development problems. At least 1 in 5 women in high-income countries used an opioid during pregnancy. : Health

The post title is a copy and paste from the second paragraph of the linked popular press article here:

Children who were prenatally exposed to opioids went on to have lower IQ scores than those who weren’t exposed to the medications, according to findings published Friday in JAMA Network Open. Those children also have more physical development problems, as well.

And this part of the introduction to the source journal article:


Prenatal opioid exposure (POE) is a fast-growing health problem, with at least 1 in 5 pregnant women in high-income countries known to have used some form of opioid during pregnancy.

Journal Reference:

Yeoh SL, Eastwood J, Wright IM, et al.

Cognitive and Motor Outcomes of Children With Prenatal Opioid Exposure: A Systematic Review and Meta-analysis.

JAMA Netw Open. Published online July 12, 20192(7):e197025.



Key Points

Question Is prenatal opioid exposure associated with differences in childhood cognitive and motor development?

Findings In this systematic review and meta-analysis of 26 studies including 1455 children exposed to prenatal opioids compared with unexposed children, prenatal opioid exposure was associated with lower cognitive scores. The largest difference was seen between ages 6 months and 6 years.

Meaning The negative consequences of prenatal opioid exposure on neurocognitive and physical development appear to be present from 6 months and persist beyond school age.


Importance Prenatal opioid exposure (POE) is one of the fastest-growing global health problems, but its association with long-term neurologic and physical development remains unknown.

Objective To assess the association between POE and cognitive and motor development in children from age 6 months to 18 years.

Data Sources Key search terms included prenatal opioid exposure, neonatal abstinence syndrome, and neurocognitive development. Studies were searched using PubMed and Embase, with no publication date restriction, through August 20, 2018.

Study Selection Only published cohort studies comparing the results of age-appropriate standardized cognitive and/or motor tests between children with any POE (aged 0-18 years) with drug-free controls were included. Data that were not convertible to means and SDs were excluded.

Data Extraction and Synthesis This study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. Data were pooled using a random-effects model.

Main Outcomes and Measures Standardized mean difference of cognitive and motor tests between POE and nonexposed children.

Results Twenty-six peer-reviewed cohort studies were included. Cognitive outcomes were compared for a total of 1455 children with POE and 2982 nonexposed children across 3 age groups (mean [SE] age at cognitive testing was 13 [1.58] months for the toddler group; 4.5 [0.38] years for the preschool group; and 13 [2.36] years for the school-aged group). Motor outcomes were compared for 688 children with POE and 1500 nonexposed children up to age 6 years (mean [SD] age at motor testing, 2 [0.45] years). Standardized mean difference was lower in cognitive tests for children with POE at 0 to 2 years (d = −0.52; 95% CI, −0.74 to −0.31; P < .001) and 3 to 6 years (d = −0.38; 95% CI, −0.69 to −0.07; P < .001); the difference was not significant for those aged 7 to 18 years (d = −0.44; 95% CI, −1.16 to 0.28; P = .23). Motor scores were lower in children with POE (d = 0.49; 95% CI, 0.23-0.74; P < .001).

Conclusions and Relevance Prenatal opioid exposure appeared to be negatively associated with neurocognitive and physical development from age 6 months, and this association persisted until adolescence. The cause and association of this with POE or other factors (eg, withdrawal treatment) are uncertain but suggest that POE necessitates long-term support and intervention.